Intestinal microbiota in nephrotic children treated with immunosuppressive agents

Repeated Administrations of Rituximab along with Steroids and Immunosuppressive Agents in Refractory Steroid-resistant Nephrotic Syndrome.

BACKGROUND A recent randomized control trial in children with steroid-resistant nephrotic syndrome revealed that two doses of rituximab did not reduce proteinuria. CASE CHARACTERISTICS A 14-month-old boy developed refractory steroid-resistant nephrotic syndrome due to focal segmental glomerulosclerosis. OBSERVATION The patient achieved complete remission 11 months after disease onset follow...

Bone Mineral Density in Children with Relapsing Nephrotic Syndrome

AbstractBackground: Given the high relapse rate of disease in children with steroid dependent nephrotic syndrome and the osteoporotic effect of long periods of steroid therapy, this survey was performed to find the bone mineral status of these patients. Methods: Bone mineral density and content (BMD and BMC) were measured using Dual energy X-ray absorptiometry in 37 nephrotic children, six girl...

Common occurrence of antibacterial agents in human intestinal microbiota

Laboratory experiments have revealed many active mechanisms by which bacteria can inhibit the growth of other organisms. Bacteriocins are a diverse group of natural ribosomally synthesized antimicrobial peptides produced by a wide range of bacteria and which seem to play an important role in mediating competition within bacterial communities. In this study, we have identified and established th...

Medicinal Plants as Immunosuppressive Agents in Traditional Iranian Medicine

The Role of Intestinal Microbiota in Cognitive Disorders

 Cognitive disorders are one of the major public health issues in older population worldwide. Problems in forming and storing new memories, short-term memory impairment, and other cognitive problems are common symptoms of cognitive disorders that have no definite treatment yet. Recent studies have shown an association between gut microbiota and cognitive impairments described as microbiota-gut-...